Nuciferine

1. Nuciferine improves osteogenic differentiation in rat cells.

   “In vitro, nuciferine promoted osteogenic differentiation and TFEB nuclear translocation in BMSCs”

   Cellsbone marrow mesenchymal stem cell

   Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy · Biomolecules · 21 Sep 2026

1. Nuciferine activates autophagy in rats.

   “it increased the microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I ratio and decreased p62 expression, as determined through Western blotting, indicating the activation of autophagy.”

   Animalsovariectomybone12 weeksfemales

   Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy · Biomolecules · 21 Sep 2026

Autophagy →

1. Nuciferine protects against osteoporosis in rats.

   “Nuciferine significantly increased bone mineral density (BMD) and improved bone microarchitecture in OVX rats”

   Animalsovariectomybone12 weeksfemales

   Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy · Biomolecules · 21 Sep 2026

Osteoporosis →