Multimorbidity
Disease3 papers5 findings
Human cohort studies link multimorbidity risk to childhood food deprivation, partly mediated by biological age, as well as to biological age uncertainty and female epigenetic puberty timing.
- Humans3
Upstream
1Light-BioAge
mediatesin humans1
1 study
Light-BioAge
mediatesin humans1
Light-BioAge mediates multimorbidity in humans (4.9% and 5.3% proportion mediated).
“Exploratory causal mediation analysis indicated that Light-BioAge accounted for a small proportion (4.9% and 5.3%) of the total effects, with indirect effects close to the null”
Humansassociation between childhood food deprivation and PPC-MMn = 4,546
Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging · Frontiers in nutrition · 10 Sep 2026
Associations
3Childhood food deprivation
upin humans1HR 1.17–1.43
1 study
Childhood food deprivation
upin humans1HR 1.17–1.43
Childhood food deprivation raises the risk of multimorbidity in humans (HR 1.43, 95% CI: 1.25-1.63).
“Further adjustment for lifestyle and health-related covariates yielded HRs of 1.17 (95% CI: 1.07-1.28) and 1.43 (95% CI: 1.25-1.63).”
Humansextreme deprivation, fully adjusted model2011-2020n = 4,546
Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging · Frontiers in nutrition · 10 Sep 2026
Childhood food deprivation raises the risk of multimorbidity in humans (HR 1.17, 95% CI: 1.07-1.28).
“Further adjustment for lifestyle and health-related covariates yielded HRs of 1.17 (95% CI: 1.07-1.28) and 1.43 (95% CI: 1.25-1.63).”
Humansmoderate deprivation, fully adjusted model2011-2020n = 4,546
Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging · Frontiers in nutrition · 10 Sep 2026
Epigenetic puberty
upin humans1
1 study
Epigenetic puberty
upin humans1
Epigenetic puberty is associated with multimorbidity in humans (standardized coefficients, 0.10 to 0.16).
Humansin HRSfemalesn = 2,106
Epigenetic puberty index tracks biological aging and adult health risks · medRxiv · 30 Sep 2026 · Preprint
Biological age uncertainty
upin humans1
1 study
Biological age uncertainty
upin humans1
Biological age uncertainty raises the risk of multimorbidity in humans.
Humansindependently of BAG
Biological age uncertainty independently predicts mortality and health decline in humans · medRxiv · 28 Sep 2026 · Preprint
Latest
6Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
Biological age uncertainty independently predicts mortality and health decline in humans
Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.
Machine learning frailty index from healthcare claims predicts mortality and disability
Integrating diagnoses, medications, and procedures into a 63-item tool outperformed an established multimorbidity index in adults aged 50 and older.