Biological aging for the advancement of biogerontology: Between hopes and hypes
Marzetti E, Picca A
The Journal of Nutrition, Health & Aging · 26 Sep 2026
Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants.
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.
A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.
