Amyotrophic lateral sclerosis
Disease7 papers1 findingMeSH D000690
- Cells2
Associations
1TARDBP
upin humans1
1 study
TARDBP
upin humans1
TARDBP is associated with amyotrophic lateral sclerosis in humans.
Review
Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
Latest
9Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.
Loss of adenosine deaminase impairs DNA repair and triggers astrocyte senescence in ALS
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.