Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans
microPublication biology · Johnson E et al. · Paper published 14 Sep 2026
From the abstract
The mechanistic target of rapamycin (mTOR), a protein kinase and master cell regulator, is one of the most validated longevity drug targets: mTOR inhibition by compounds like rapamycin has been shown to significantly extend lifespan in numerous model organisms.
Shared under the paper’s CC BY licence.
The paper
Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans
Johnson E, Sedore CA, Coleman-Hulbert AL et al.
microPublication biology · 14 Sep 2026 · Peer-reviewed
- Relevance
- Core geroscience
- News value
- Notable
- Evidence
- Model organisms
- Status
- Peer-reviewed
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