mTOR inhibitors
Intervention6 papers9 findings
Rapamycin inhibits cellular senescence in human cells and mouse tumours, where it also inhibits mTOR signalling and activates autophagy. In mice, it protects against bleomycin-induced pulmonary fibrosis, whilst reviews describe its inhibition of mTOR signalling.
- Animals5
- Cells1
Outcomes
7Cellular senescence
downin human cells1downin mice1
2 studies
Cellular senescence
downin human cells1downin mice1
Rapamycin inhibits cellular senescence in human cells.
Cellsepithelial cell
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
Rapamycin decreases cellular senescence in mice.
Animalstherapy-induced senescence in chemoresistant lung cancertumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
mTOR signalling
downin mice1downin reviews1
2 studies
mTOR signalling
downin mice1downin reviews1
Rapamycin inhibits mTOR signalling.
Review
Rapamycin across biology and medicine: From molecular mechanisms to clinical and translational frontiers · Biochimica et biophysica acta. General subjects · 24 Sep 2026
Rapamycin inhibits mTOR signalling in mice.
Animalsin chemoresistant lung cancertumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
Whole-aorta lipid-positive area
downin mice1
1 study
Whole-aorta lipid-positive area
downin mice1
Rapamycin decreases whole-aorta lipid-positive area in mice (from 25.32 ± 0.98% to 12.28 ± 1.49%).
Animalshigh-fat diet-induced atherosclerosisaorta1 mg/kg4 weeksn = 6
Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice · International immunopharmacology · 2 Oct 2026
Plaque efferocytosis index
upin mice1
1 study
Plaque efferocytosis index
upin mice1
Rapamycin improves plaque efferocytosis index in mice (from 0.36 ± 0.02 to 1.37 ± 0.15).
Animalshigh-fat diet-induced atherosclerosisatherosclerotic plaque1 mg/kg4 weeksn = 6
Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice · International immunopharmacology · 2 Oct 2026
Pulmonary fibrosis
downin mice1
1 study
Pulmonary fibrosis
downin mice1
Rapamycin protects against pulmonary fibrosis in mice.
Animalsbleomycin-induced pulmonary fibrosislung
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
SFN
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1 study
SFN
downin human cells1
Rapamycin decreases SFN in human cells.
CellsA549
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice · Research Square · 28 Sep 2026 · Preprint
Autophagy
upin mice1
1 study
Autophagy
upin mice1
Rapamycin activates autophagy in mice.
Animalstumor
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer · Biomaterials · 23 Sep 2026
Latest
9Rapamycin reduces ferroptotic stress and shrinks atherosclerotic plaques in mice
The mTOR inhibitor restored macrophage efferocytosis and mitochondrial function while lowering aortic lipid burden in high-fat-fed ApoE-deficient mice.
Inhalable nanoliposomes target senescence and overcome chemoresistance in mouse lung cancer
The formulation co-delivers rapamycin and doxorubicin across the mucus barrier to inhibit mTOR and suppress tumor growth without evident systemic toxicity.
Dietary CoQ10 improves megakaryocyte function and reduces platelet hyperreactivity in aging mice
The supplement boosted autophagy via COPS3, enhancing megakaryocyte maturation and polyploidization without altering baseline platelet counts.
Rapamycin slows pulmonary fibrosis by reducing lung epithelial cell senescence in mice
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
Circulating alpha-synuclein promotes atherosclerosis by impairing macrophage autophagy
Targeting FLOT1 or downstream PI3K-mTOR signaling counteracted the vascular lipid accumulation driven by extracellular alpha-synuclein in mouse models.
FUNDC1 protects skin against UVA damage through mitophagy and P53 stability
Researchers identified a molecular pathway where FUNDC1 preserves mitochondrial quality and works with BAZ1B to regulate P53 during skin photoaging.