TARDBP
GeneHomo sapiens4 papers2 findingsHGNC 11571NCBI Gene 23435Taxon 9606
- Humans1
- Cells2
Associations
2Amyotrophic lateral sclerosis
upin humans1
1 study
Amyotrophic lateral sclerosis
upin humans1
TARDBP is associated with amyotrophic lateral sclerosis in humans.
Review
Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
Frontotemporal lobar degeneration
upin humans1
1 study
Frontotemporal lobar degeneration
upin humans1
TARDBP is associated with frontotemporal lobar degeneration in humans.
Humanssomatic variantssuperior temporal gyrus
Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Latest
5Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
Loss of adenosine deaminase impairs DNA repair and triggers astrocyte senescence in ALS
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.