Frontotemporal lobar degeneration
Disease1 paper1 finding
- Humans1
Associations
1TARDBP
upin humans1
1 study
TARDBP
upin humans1
TARDBP is associated with frontotemporal lobar degeneration in humans.
Humanssomatic variantssuperior temporal gyrus
Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Latest
1Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.