CDKN1A
GeneHomo sapiens9 papers2 findingsHGNC 1784NCBI Gene 1026Taxon 9606
- Humans1
- Animals2
- Cells6
Interventions
1Ormeloxifene
upin human cells1
1 study
Ormeloxifene
upin human cells1
Ormeloxifene increases CDKN1A in human cells.
CellsMCF-7
Ormeloxifene, a non-steroidal selective estrogen receptor modulator induces senescence in breast cancer cells · Molecular biology reports · 1 Oct 2026
Associations
1Osteoarthritis
downin silico1
1 study
Osteoarthritis
downin silico1
Osteoarthritis is associated with CDKN1A in silico (AUC 0.931).
“CDKN1A, CDK6, and WEE1 were reduced in OA-associated meniscal samples in GSE98918; within-dataset ROC analyses yielded AUCs of 0.931, 0.882, and 0.792, respectively.”
In silicomeniscus
Senescence-Associated Checkpoint Gene Dysregulation in Established Osteoarthritis: Integrated Transcriptomic Analysis and In Vitro Evaluation of CDK6 and WEE1 · Biomedicines · 26 Aug 2026
Latest
10DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Loss of PP4 drives airway senescence through endoplasmic reticulum stress
Inhibiting the PERK pathway lowered cellular senescence and inflammatory markers in mouse models and cultured human airway cells.
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.