Senescence-associated beta-galactosidase
Biomarker12 papers3 findings
- Animals3
- Model organisms1
- Cells8
Interventions
3Cedrus deodara flavonoids
downin mice1
1 study
Cedrus deodara flavonoids
downin mice1
Cedrus deodara flavonoids decrease senescence-associated beta-galactosidase in mice.
Animalsozone-induced aging modeldeep eutectic solvent extract50, 100, 200 mg/kg14 days
Green Extraction of Flavonoids from Cedrus deodara Pollen with Deep Eutectic Solvents and Their Potential Anti-Senescence Properties · Research Square · 29 Sep 2026 · Preprint
Leptin
downin pig cells1
1 study
Leptin
downin pig cells1
Leptin decreases senescence-associated beta-galactosidase in pig cells.
Cellsunder heat stressSertoli cellmales
Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling · Journal of animal science · 26 Sep 2026
Buddleja globosa
downin human cells1
1 study
Buddleja globosa
downin human cells1
Buddleja globosa decreases senescence-associated beta-galactosidase in human cells.
“BgAE reduced H 2 O 2 -induced β-galactosidase positivity at 1 and 50 μg/mL and modulated TNFA , p16, p21, and NF-κB responses”
Cellsin H2O2-treated THP-1-derived macrophagesaqueous extractTHP-1-derived macrophage1 and 50 μg/mL48 h
Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages · Pharmaceuticals (Basel, Switzerland) · 12 Sep 2026
Latest
12Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria
Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.
Killifish exhibit distinct structural changes and fibrosis during cardiac aging
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.