Age-related hearing loss
Disease3 papers2 findings
- Humans1
- Animals1
Associations
2Mitochondrial dysfunction
upin reviews1
1 study
Mitochondrial dysfunction
upin reviews1
Mitochondrial dysfunction is associated with age-related hearing loss.
Reviewcochlea
Therapeutic Timing at Mitochondrial Redox-Autophagy-Mitophagy Checkpoints in Age-Related Hearing Loss · Molecular neurobiology · 30 Sep 2026
Igf1
downin mice1
1 study
Igf1
downin mice1
Igf1 is associated with age-related hearing loss in mice.
“Transcriptomics revealed significant downregulation of Igf1 and Slc25a33 in aged pericytes, with enrichment of the TGF-β signaling pathway.”
Animalspericyte
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Latest
4Auditory nerve myelin degeneration defines a subtype of age-related hearing loss
Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.
Gut microbes from hearing loss patients trigger inner ear damage in young mice
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.