Igf1
GeneMus musculus1 paper2 findingsMGI 96432NCBI Gene 16000Taxon 10090
- Animals1
Effects
1Mitochondrial dysfunction
downin mouse cells1
1 study
Mitochondrial dysfunction
downin mouse cells1
Igf1 decreases mitochondrial dysfunction in mouse cells.
“IGF-1 deficiency suppressed SLC25A33 expression in vitro, leading to mitochondrial ROS (mtROS) accumulation”
CellsIGF-1 deficiency in vitropericyte
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Associations
1Age-related hearing loss
downin mice1
1 study
Age-related hearing loss
downin mice1
Igf1 is associated with age-related hearing loss in mice.
“Transcriptomics revealed significant downregulation of Igf1 and Slc25a33 in aged pericytes, with enrichment of the TGF-β signaling pathway.”
Animalspericyte
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice · Aging cell · 30 Sep 2026
Latest
1Animals
IGF-1 and SLC25A33 preserve cochlear blood barrier integrity in aged mice
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.