Cellular senescenceCells28 Sep 2026

Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling

Journal of Animal Science

The paper

Guo M, Gao Y, Zhang J et al.

Journal of Animal Science · 26 Sep 2026

doi.org/10.1093/jas/skag314 PubMed

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Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling

The paper

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Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

A distinct p21-driven macrophage senotype accumulates during aging and liver disease

DNA methylation proxies of senescence markers track human disease and mortality

Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates

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