mtDNA
Biomarker2 papers
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13Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
AnimalsMitochondria
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
AnimalsMitochondria
D-allose attenuates intervertebral disc degeneration by targeting a mitochondrial stress pathway
The rare sugar enhances mitophagy, blocks cGAS-STING signaling, and protects nucleus pulposus cells from senescence and apoptosis.
Crebanine protects aged rats from anesthesia-induced cognitive deficits by restoring mitophagy
The compound suppresses mitochondrial DNA leakage and the cGAS-STING inflammatory pathway in microglial cells following sevoflurane exposure.
Early-life mitochondrial DNA mutations drive age-related pathology in mice
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.