mTORC1 signalling
Pathway5 papers1 findingGO 0038202
- Animals3
- Cells1
- In silico1
Interventions
1ULK1 knockout + ULK2 knockout
upin mice1
1 study
ULK1 knockout + ULK2 knockout
upin mice1
ULK1 knockout + ULK2 knockout activates mTORC1 signalling in mice.
Animalsindependent of AKTskeletal muscle
Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Latest
5Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1
Inhibiting mTORC1 restored autophagy, reduced amyloid accumulation, and corrected circuit desynchronization and behavioral deficits in stressed Alzheimer model mice.