Exploring the Neuroprotective Effects of Walnut (Juglans regia L.) Against Cognitive Impairment in Alzheimer's Disease Through the MAPK-mTORC1-TFEB-Mediated Endolysosomal Pathway: A Network Pharmacology and Molecular Docking Approach
Abstract · CC BY
Alzheimer's disease (AD) is a complex neurodegenerative disorder with multifaceted pathogenesis. Given the clinical need for multi-target interventions, this study elucidated the neuroprotective mechanisms of walnut ( Juglans regia L.) against AD-related cognitive impairment.
- Gallic acid
- Juglans regia
- Pedunculagin
- Strictinin
- Tellimagrandin i
- Disabled macroautophagy
- Loss of proteostasis
- Autophagy
- MAPK/ERK signalling
- mTORC1 signalling
- ABCA1
- TFEB
The paper
Exploring the Neuroprotective Effects of Walnut (Juglans regia L.) Against Cognitive Impairment in Alzheimer's Disease Through the MAPK-mTORC1-TFEB-Mediated Endolysosomal Pathway: A Network Pharmacology and Molecular Docking Approach
Lin CT, Chen KT, Hung YC
International Journal of Molecular Sciences · 17 Sep 2026