ULK1 knockout + ULK2 knockout
Intervention1 paper4 findings
- Animals1
Outcomes
4mTORC1 signalling
upin mice1
1 study
mTORC1 signalling
upin mice1
ULK1 knockout + ULK2 knockout activates mTORC1 signalling in mice.
Animalsindependent of AKTskeletal muscle
Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Skeletal muscle
upin mice1
1 study
Skeletal muscle
upin mice1
ULK1 knockout + ULK2 knockout induces skeletal muscle in mice (10-15% in males, 14-20% in females).
Animalstibialis anterior and soleus
Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Physical function
downin mice1
1 study
Physical function
downin mice1
ULK1 knockout + ULK2 knockout impairs physical function in mice (20% in males, 24% in females).
Animalslifelong deficiencyskeletal muscle
Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Autophagy
downin mice1
1 study
Autophagy
downin mice1
ULK1 knockout + ULK2 knockout impairs autophagy in mice.
Animalslifelong deficiencyskeletal muscle
Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force · bioRxiv : the preprint server for biology · 10 Sep 2026 · Preprint
Latest
1Loss of ULK1 and ULK2 drives muscle growth in mice but impairs force
While lifelong depletion reduced muscle strength, short-term deficiency in adult mice induced hypertrophy without degrading muscle quality or contractile performance.