Danio rerio
Organism4 papers4 findingsTaxon 7955MeSH D015027
- Model organisms2
Interventions
3Telomir-zn
downoxidative stress and ROS signalling1upvisual behaviors1
1 study
Telomir-zn
downoxidative stress and ROS signalling1upvisual behaviors1
Telomir-zn improves visual behaviors in zebrafish.
“Telomir-Zn reduced oxidative stress, preserved retinal architecture, improved visual behaviors, and partially normalized telomeric content and CpG methylation patterns.”
Animalsin Sen57 wrn-/- ND6-/+ zebrafish
Targeted metal modulation preserves retinal structure and vision in zebrafish · International journal of molecular sciences · 16 Sep 2026
Telomir-zn decreases oxidative stress and ROS signalling in zebrafish.
“Telomir-Zn reduced oxidative stress, preserved retinal architecture, improved visual behaviors”
Animalsin Sen57 wrn-/- ND6-/+ zebrafishretina
Targeted metal modulation preserves retinal structure and vision in zebrafish · International journal of molecular sciences · 16 Sep 2026
Navitoclax
downsenescent cell1
1 study
Navitoclax
downsenescent cell1
Navitoclax decreases senescent cell in zebrafish.
Animalsin cells with high UHRF1 levelshepatocyte
UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026
UHRF1 overexpression
upcellular senescence1
1 study
UHRF1 overexpression
upcellular senescence1
UHRF1 overexpression induces cellular senescence in zebrafish.
Animalshepatocyte
UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026
Latest
4UHRF1 levels drive distinct senescent states in zebrafish liver cells
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.
Targeted metal modulation preserves retinal structure and vision in zebrafish
Telomir-Zn depleted labile iron, lowered oxidative stress, and improved visual behaviors and epigenetic marks in zebrafish and cultured human retinal cells.