UHRF1 overexpression
Intervention1 paper1 finding
- Model organisms1
Outcomes
1Cellular senescence
upin zebrafish1
1 study
Cellular senescence
upin zebrafish1
UHRF1 overexpression induces cellular senescence in zebrafish.
Animalshepatocyte
UHRF1 levels drive distinct senescent states in zebrafish liver cells · EMBO reports · 28 Sep 2026
Latest
1Model organismsCellular senescence
UHRF1 levels drive distinct senescent states in zebrafish liver cells
High UHRF1 expression causes stable senescence sensitive to Navitoclax, while cells with lower expression proliferate if tp53 is mutated.