Fibrosis
Disease5 papers2 findingsMeSH D005355
- Humans1
- Animals2
Interventions
2Shikonin
downin rats1
1 study
Shikonin
downin rats1
Shikonin decreases fibrosis in rats.
Animalsdoxorubicin-induced cardiotoxicitymyocardiummales
Shikonin attenuates doxorubicin-induced myocardial senescence and fibrosis in association with improved redox and mitochondrial homeostasis · Molecular biology reports · 28 Sep 2026
AGTR2 knockout
upin mice1
1 study
AGTR2 knockout
upin mice1
AGTR2 knockout increases fibrosis in mice.
Animalsheart
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice · Clinical science (London, England : 1979) · 25 Sep 2026
Latest
29Ovarian stiffness and fibrosis mark reproductive aging in women
Shear wave elastography and transcriptomic profiling show that ovarian fibrosis correlates with reduced oocyte yield and follicular efficiency.
Ovarian stiffness increases with age and tracks with declining egg yield
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.
Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models
Computational screening identified the natural compound, which interacts with CHK1 to blunt replication stress and fibrotic signaling.
Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis
Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.