Trp53
GeneMus musculus11 papers1 findingMGI 98834NCBI Gene 22059Taxon 10090
- Animals10
- Cells1
Effects
1Cdkn2a
downin mouse cells1
1 study
Cdkn2a
downin mouse cells1
Trp53 inhibits Cdkn2a in mouse cells.
Cellsin senescent macrophagesmacrophage
A distinct p21-driven macrophage senotype accumulates during aging and liver disease · bioRxiv · 28 Sep 2026 · Preprint
Latest
11Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FUNDC1 protects skin against UVA damage through mitophagy and P53 stability
Researchers identified a molecular pathway where FUNDC1 preserves mitochondrial quality and works with BAZ1B to regulate P53 during skin photoaging.
Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice
The herbal extract activates AMPK-SIRT1 signaling, enhancing antioxidant defenses and modulating apoptosis to alleviate tissue aging across both model organisms.
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.