DNAmTL
Biomarker3 papers4 findings
Human studies associate DNAmTL with cognitive function, PhenoAge, and cholestatic liver disease, with one study showing decreased levels in primary sclerosing cholangitis.
- Humans3
Upstream
1Primary sclerosing cholangitis
downin humans1
1 study
Primary sclerosing cholangitis
downin humans1
Primary sclerosing cholangitis decreases DNAmTL in humans (median -0.036 vs. 0.016).
Humanscompared with controls
Telomere attrition marks disease severity in chronic cholestatic liver diseases · Alimentary pharmacology & therapeutics · 29 Sep 2026
Associations
3Cholestatic liver disease
downin humans1
1 study
Cholestatic liver disease
downin humans1
Cholestatic liver disease is associated with DNAmTL in humans.
Humans
Telomere attrition marks disease severity in chronic cholestatic liver diseases · Alimentary pharmacology & therapeutics · 29 Sep 2026
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
Cognitive function is associated with DNAmTL in humans (6.39 ± 0.27 vs 5.39 ± 0.21 kb; Cohen's d = 4.15).
Humansin Healthy Cognitive Agers aged ≥80 years maintaining MMSE = 30n = 80
Older adults with preserved cognition show slower biological aging and longer telomeres · Aging and disease · 23 Sep 2026
PhenoAge
downin humans1
1 study
PhenoAge
downin humans1
DNAmTL is associated with PhenoAge in humans.
“DNAmTL was inversely associated with both domains and did not differ significantly across domains.”
Humansboth mitotic and early-life systemic dysregulation domainsblood
Blood methylation clocks capture two distinct biological domains of aging · Genes · 9 Sep 2026
Latest
3Older adults with preserved cognition show slower biological aging and longer telomeres
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.
Telomere attrition marks disease severity in chronic cholestatic liver diseases
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.
Blood methylation clocks capture two distinct biological domains of aging
Specific epigenetic measures track mitotic cell replication, while others capture systemic dysregulation driven by inflammation, metabolic factors, and lifestyle exposures.