Lipofuscin
Biomarker5 papers3 findingsMeSH D008062
In worm studies, pimozide and sonnerachromones a–g decrease lipofuscin, whereas musk ketone increases it at concentrations of 0.4 to 20 mg/L over 24 hours.
- Model organisms4
- Cells1
Interventions
3Sonnerachromones a–g
downin worms1
1 study
Sonnerachromones a–g
downin worms1
Sonnerachromones a–g decreases lipofuscin in worms.
Model organisms
Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint
Pimozide
downin worms1
1 study
Pimozide
downin worms1
Pimozide decreases lipofuscin in worms.
“pimozide improves healthspan, as evidenced by reduced age-related lipofuscin accumulation, preserved locomotor function, and decreased paralysis incidence.”
Model organisms
Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026
Musk ketone
upin worms1
1 study
Musk ketone
upin worms1
Musk ketone increases lipofuscin in worms.
Model organisms0.4 to 20 mg/L24 h
Assessing the toxicological effects of synthetic musk ketone using the Caenorhabditis elegans model · BMC pharmacology & toxicology · 9 Sep 2026
Latest
5Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes
The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans.