Retinal degeneration
Disease2 papers2 findingsMeSH D012162
- Animals1
- Model organisms1
Interventions
1LGALS3 knockout
downin mice1
1 study
LGALS3 knockout
downin mice1
LGALS3 knockout protects against retinal degeneration in mice.
Animalslater-stage degeneration under prolonged lipid burdenretina
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint
Upstream
1Apoe
downin mice1
1 study
Apoe
downin mice1
Apoe protects against retinal degeneration in mice.
Animalsvia oxidized lipid cargo disposal to subretinal microglianeural retina
Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice · bioRxiv · 28 Sep 2026 · Preprint
Latest
3Lack of dietary DHA drives harmful lipid remodeling and retinal degeneration in mice
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.
Targeted metal modulation preserves retinal structure and vision in zebrafish
Telomir-Zn depleted labile iron, lowered oxidative stress, and improved visual behaviors and epigenetic marks in zebrafish and cultured human retinal cells.