Neuroinflammation
Disease1 paper1 finding
- Animals1
Interventions
1Src inhibitor
downin mice1
1 study
Src inhibitor
downin mice1
Src inhibitor decreases neuroinflammation in mice.
Animalslipopolysaccharide-induced
Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice · Biochemical pharmacology · 25 Sep 2026
Latest
33Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
Gut microbes from hearing loss patients trigger inner ear damage in young mice
Fecal transplants from elderly hearing loss patients induced blood-labyrinth barrier breakdown, neuroinflammation, and hair cell loss in recipient mice.
Biomimetic nanozymes reduce neuroinflammation and cognitive decline in aged mice
Neutrophil-coated nanoparticles crossed the blood-brain barrier, altered microglial metabolism, and improved cognitive performance after surgery in older mice.
Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice
The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate
Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.
Oral 4-methylumbelliferone remodels brain extracellular matrix and improves memory in aged mice
The compound reduced perineuronal nets, dampened glial activation, and cut immune cell infiltration while restoring recognition memory.