Cognitive deficits

Disease2 papers2 findings

Interventions

Icariin

downin mice1

1 study

Icariin decreases cognitive deficits in mice.
Animalsin APP/PS1 mice
Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice · Chinese journal of natural medicines · 1 Oct 2026

Src inhibitor

downin mice1

1 study

Src inhibitor decreases cognitive deficits in mice.
Animalsin LPS-challenged mice
Blocking Src kinase reduces neuroinflammation by activating microglial mitophagy in mice · Biochemical pharmacology · 25 Sep 2026

The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.

Chinese Journal of Natural Medicines · Fan L et al.

AnimalsPreprintMitochondria29 Sep

The compound suppresses mitochondrial DNA leakage and the cGAS-STING inflammatory pathway in microglial cells following sevoflurane exposure.

Research Square · Zheng G et al.

AnimalsBrain aging29 Sep

The combined regimen lowered TMAO accumulation and suppressed inflammatory signaling more effectively than cognitive training alone.

Molecular Neurobiology · Zhang R et al.

AnimalsMitochondria26 Sep

Inhibiting the kinase reduced p62 UFMylation to promote ubiquitination and mitochondrial clearance, alleviating cognitive deficits in mice.

Biochemical Pharmacology · Dong YR et al.

AnimalsBrain aging26 Sep

The targeted nanoplatform cleared amyloid deposits and suppressed neuroinflammation in an Alzheimer's model by inhibiting mTOR signaling.

Nanomedicine · Sun C et al.

AnimalsThe Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

26 Sep