Hepatic steatosis

Disease2 papers1 finding

Animals2

Interventions

1

Ghr knockout

upin mice1

1 study

Ghr knockout induces hepatic steatosis in mice.
“Elevated circulating GH following hepatocyte-specific GHR ablation mediates adipose-liver crosstalk that promotes adipose lipolysis and CD36-dependent hepatic steatosis.”
Animalshepatocyte-specifichepatocyte-specific knockoutliver
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

Ghr knockout →

Latest

2

Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features

AnimalsBiomedicines

26 Sep

AnimalsMitochondria26 Sep

Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice

The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.

Aging Cell · Yang K et al.