Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features
Abstract · CC BY
Objective: To evaluate whether structural entropy of liver histological sections reflects tissue disorganization in a rat model of constant light exposure (dark deprivation) and to explore its associations with morphofunctional parameters of hepatic remodeling.
- Constant light exposure
- Cellular senescence
- Mitochondrial dysfunction
- Circadian clock
- p16INK4a–RB pathway
- p53–p21 pathway
- Arntl
- Cdkn1a
- Cdkn2a
- Clock
- Mki67
- Per2
The paper
Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features
Areshidze DA, Gladyshev NS, Kozlova MA et al.
Biomedicines · 31 Aug 2026