Ghr knockout

1. Ghr knockout induces hepatic steatosis in mice.

   “Elevated circulating GH following hepatocyte-specific GHR ablation mediates adipose-liver crosstalk that promotes adipose lipolysis and CD36-dependent hepatic steatosis.”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

Hepatic steatosis →

1. Ghr knockout impairs cognitive function in mice.

   “reduced metabolic stress resilience, cognitive decline, impaired bone mineralization, and exacerbated inflammaging.”

   Animalshepatocyte-specifichepatocyte-specific knockout

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

1. Ghr knockout increases cellular senescence in mice.

   “hepatocyte-specific GHR knockout mice display accelerated aging-related phenotypes, characterized by shortened lifespan, enhanced cellular senescence”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026

Cellular senescence →

1. Ghr knockout shortens lifespan in mice.

   “hepatocyte-specific GHR knockout mice display accelerated aging-related phenotypes, characterized by shortened lifespan”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice · Aging cell · 26 Sep 2026