Age-specific genomic and transcriptomic variation reveals limited evidence for cis-regulatory interactions modulating aging in Saccharomyces cerevisiae
McHugh KM, Barreto FS, Burke MK
G3 · 3 Oct 2026
Melanin protects against mitochondrial genome damage and clonal expansion in chronically sun-exposed human skin.Melanin protects against mitochondrial genome damage and clonal expansion in chronically sun-exposed human skin. In an observational study of six older men, researchers analyzed how skin pigmentation influences mitochondrial DNA (mtDNA) stability under chronic sun exposure.
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean…Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects. In a new mouse model of cesarean section scar defects, researchers investigated the mechanisms that disrupt uterine healing.
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice. In experiments using cultured myoblasts, mice, and human tissues, researchers investigated how calcium overload hinders skeletal muscle regeneration.
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway. In female mice experiencing reproductive aging, administration of the peptide elamipretide increased litter size and ameliorated age-related declines in oocyte…
