Calcific aortic valve disease
Disease2 papers1 finding
- Humans1
- Animals1
Interventions
1SRT2104
downin mice1
1 study
SRT2104
downin mice1
SRT2104 protects against calcific aortic valve disease in mice.
AnimalsWestern diet-fed Apoe-/-aortic valve
Activating Sirt1 reduces aortic valve calcification in mice and human cells · International journal of molecular medicine · 25 Sep 2026
Latest
2ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
AnimalsNAD+ & sirtuins
Activating Sirt1 reduces aortic valve calcification in mice and human cells
The sirtuin protects valves by activating the Nrf2 pathway, preserving mitochondrial function, and preventing iron-driven ferroptosis.