Prodh2
GeneMus musculus1 paper1 findingMGI 1929093NCBI Gene 56189Taxon 10090
- Animals1
Effects
1cGAS–STING signalling
upin mouse cells1
1 study
cGAS–STING signalling
upin mouse cells1
Prodh2 activates cGAS–STING signalling in mouse cells.
Cellsvia mitochondrial reactive oxygen species and cytosolic mtDNA releasemyoblast
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice · Aging cell · 1 Oct 2026
Latest
1AnimalsMitochondria
Prodh2 inhibition alleviates muscle atrophy and restores strength in COPD mice
TNF-alpha triggers a mitochondrial immune pathway via Prodh2 that damages myoblasts, while silencing the enzyme restores muscle strength in mice.