Tau pathology
Disease1 paper
- Animals1
Latest
5Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
Astrocytic secretome enhances hippocampal neurogenesis and spatial memory in mice
Treatment with astrocyte-conditioned solution also rescued cognitive deficits and lowered inflammation in mouse models of Alzheimer's disease.
HumansBrain aging
Peripheral immune cell profiles predict cognitive decline in older adults
An immune risk score tracking immunosenescence correlated with markers of neural injury and neuroinflammation rather than classical amyloid or tau pathology.
AnimalsBrain aging
Aging rhesus macaques display distinct fluid proteomic signatures of senescence and neuropathology
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.