Neurodegenerative disorders

Latest

HumansPreprintBrain agingYesterday

Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains

Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.

bioRxiv · Bidhan V et al.

Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants

Model organismsPreprintbioRxiv

Yesterday

Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease

Model organismsGene

Yesterday

Ferroptosis-Driven Inflammaging in Age-Associated Degenerative Disorders: Molecular Mechanisms and Therapeutic Potential of Natural Products

ReviewAgeing Research Reviews

Yesterday

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

ReviewMedComm

Yesterday

Cellular and systemic modifiers of alpha-synuclein proteostasis

ReviewPhilosophical Transactions of the Royal Society of London. Series B, Biological Sciences

1 Oct

Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease

ReviewPhilosophical Transactions of the Royal Society of London. Series B, Biological Sciences

1 Oct

AnimalsMitochondria1 Oct

Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice

The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.

Chinese Journal of Natural Medicines · Fan L et al.

Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies

ReviewAgeing Research Reviews

1 Oct

Sleep and circadian regulation of DNA repair and retrotransposons in neuronal genome stability and neurodegenerative disease mechanisms

ReviewFrontiers in Neuroscience

1 Oct