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Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.
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Cells·Preprint
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · 1 Oct · Alsolami S, Wang M, Sarraf Sabedot T et al.
Humans·Peer-reviewed
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.
Science advances · 30 Sept · Hernandez H, Pedraza LK, Santamaria-Garcia H et al.
Humans·Peer-reviewed
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 1 Oct · Mostafaei S, Gustavsson K, Hagelin H et al.
Animals·Peer-reviewed
Researchers identified ghrelin as a key metabolic factor that reduces microglial senescence and inflammation through the SHBG/JNK1/Beclin1 signaling axis.
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