Liver fibrosis

1. Camellia sinensis decreases liver fibrosis in mice.

   Animalsin D-galactose-induced agingNongxiang-type Tieguanyin extractliver110 or 550 mg/kg/day8 weeks

   Protective Effects of Nongxiang-Type Tieguanyin on the Liver of D-Galactose-Induced Aging C57BL/6 Mice via the NF-κB Signaling Pathway · Food science & nutrition · 29 Sep 2026

Camellia sinensis →

1. NOS3 knockout increases liver fibrosis in mice.

   “In human fibrotic liver samples and mouse models, eNOS expression is markedly suppressed, and its hepatocyte-specific deletion aggravates injury and fibrosis.”

   Animalshepatocyte-specifichepatocyte-specific knockoutliver

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

NOS3 knockout →

1. Intermittent fasting protects against liver fibrosis in mice.

   “We further establish that the anti-fibrotic benefits of alternate-day fasting (ADF) critically depend on this intercellular pathway.”

   Animalsalternate-day fastingliver

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Intermittent fasting →

1. Nos3 is required for liver fibrosis in mice.

   “ADF enhanced hepatocyte eNOS expression, and hepatocyte-specific eNOS knockout abolished the protective metabolic and anti-fibrotic effects of ADF.”

   Animalsfor alternate-day fasting-mediated protectionhepatocyte

   Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026

Nos3 →