NOS3 knockout
Intervention1 paper1 finding
- Animals1
Outcomes
1Liver fibrosis
upin mice1
1 study
Liver fibrosis
upin mice1
NOS3 knockout increases liver fibrosis in mice.
“In human fibrotic liver samples and mouse models, eNOS expression is markedly suppressed, and its hepatocyte-specific deletion aggravates injury and fibrosis.”
Animalshepatocyte-specifichepatocyte-specific knockoutliver
Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 27 Sep 2026
Latest
1AnimalsDietary restriction
Alternate-day fasting resolves liver fibrosis via hepatocyte eNOS signaling
Nitric oxide produced by hepatocytes during fasting blocks autophagy in stellate cells to halt fibrotic progression in mice.