Shikonin

1. Shikonin inhibits p53–p21 pathway in rats.

   Animalsdoxorubicin-treated

   Shikonin attenuates doxorubicin-induced myocardial senescence and fibrosis in association with improved redox and mitochondrial homeostasis · Molecular biology reports · 28 Sep 2026

p53–p21 pathway →

1. Shikonin decreases fibrosis in rats.

   Animalsdoxorubicin-induced cardiotoxicitymyocardiummales

   Shikonin attenuates doxorubicin-induced myocardial senescence and fibrosis in association with improved redox and mitochondrial homeostasis · Molecular biology reports · 28 Sep 2026

Fibrosis →

1. Shikonin decreases cellular senescence in rats.

   Animalsdoxorubicin-induced cardiotoxicitymyocardiummales

   Shikonin attenuates doxorubicin-induced myocardial senescence and fibrosis in association with improved redox and mitochondrial homeostasis · Molecular biology reports · 28 Sep 2026

Cellular senescence →