Search results for Alzheimer's disease
160 results
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
- AnimalsMitochondria
Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice
The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.
- AnimalsMitochondria
Mitochondrial antioxidant MitoQ reduces Alzheimer's pathology in symptomatic mice
Oral treatment improved behavioral deficits, suppressed amyloid plaques, lowered neuroinflammation, and restored mitochondrial quality control in mice with established disease.
- AnimalsBrain aging
Intranasal Arc-engineered exosomes reduce Alzheimer pathology by restoring autophagy
The targeted nanoplatform cleared amyloid deposits and suppressed neuroinflammation in an Alzheimer's model by inhibiting mTOR signaling.
- CellsBrain aging
Astrocytic BAG3 regulates protein clearance systems linked to Alzheimer disease
Loss of the chaperone mediator in human astrocytes disrupts autophagy, proteasomes, and retromer traffic while impairing amyloid-beta proteostasis in neuron cocultures.
- HumansBrain aging
Biological aging clocks combined with genetics improve dementia risk prediction
Adding proteomic, metabolomic, and clinical aging measures to polygenic scores boosted prediction accuracy in two large human cohorts.
- HumansBrain aging
Speech clocks reflect dementia phenotypes and biological aging markers
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.