Chronic restraint stress

1. Chronic restraint stress inhibits autophagy in mice.

   “Mechanistically, transcriptomic profiling and biochemical validation revealed that chronic stress suppresses autophagic pathways via selective hyperactivation of mTORC1 signaling rather than the AMPK pathway.”

   Animalsvia selective hyperactivation of mTORC1 signaling

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

Autophagy →

1. Chronic restraint stress increases amyloid-beta in mice.

   “These network deficits were accompanied by accelerated AD hallmarks, including elevated Aβ deposition, dystrophic neurite aggravation, and reactive gliosis.”

   Animalsin 5xFAD mice

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026

Amyloid-beta →

1. Chronic restraint stress impairs cognitive function in mice.

   “CRS severely impaired cortical slow-wave oscillations and induced aberrant prefrontal single-neuron hyperactivity, exacerbating cognitive decline.”

   Animalsin 5xFAD mice

   Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026