Amyloid-beta 42
Biomarker1 paper1 finding
- Animals1
Interventions
1MHY1485
upin mice1
1 study
MHY1485
upin mice1
MHY1485 increases amyloid-beta 42 in mice.
“pharmacological mTOR activation with MHY1485 further aggravated autophagic impairment and increased Aβ42 levels.”
Animalspharmacological mTOR activation
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1 · CNS neuroscience & therapeutics · 29 Sep 2026
Latest
1AnimalsmTOR & rapamycin
Chronic stress accelerates Alzheimer pathology in mice by hyperactivating mTORC1
Inhibiting mTORC1 restored autophagy, reduced amyloid accumulation, and corrected circuit desynchronization and behavioral deficits in stressed Alzheimer model mice.