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Cellular senescenceSenescent cells, the SASP, and the drugs that clear or quiet them.
Aging clocksEpigenetic, blood-based and other measures of biological age.
mTOR & rapamycinNutrient sensing through mTOR, and the rapalogs that dial it down.
Partial reprogrammingYamanaka factors, epigenetic reprogramming and cellular rejuvenation.
NAD+ & sirtuinsNAD+ precursors, sirtuins and the metabolism of aging cells.
MitochondriaMitochondrial function, mitophagy and energy decline with age.
Dietary restrictionCaloric restriction, fasting and time-restricted eating.
GLP-1 drugsSemaglutide, tirzepatide and what incretin drugs do to aging.
InflammagingChronic low-grade inflammation and the aging immune system.
Brain agingCognitive aging, neurodegeneration and the aging brain.

TP53

GeneSus scrofa1 paperNCBI Gene 397276Taxon 9823

Cells1

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1

Leptin mitigates heat stress-induced senescence in porcine Sertoli cells through modulation of ATM-p53, ERK1/2, and AMPK-mTORC1 signaling

CellsJournal of Animal Science

·28 Sep

Related

AMPK signalling1
ATM1
Autophagy1
Cellular senescence1
DNA damage response1
Disabled macroautophagy1
Genomic instability1
MAPK/ERK signalling1
Senescence-associated secretory phenotype (SASP)1
Heat stress1
Leptin1
mTORC1 signalling1
Male infertility1
p53–p21 pathway1
Reactive oxygen species1
Senescence-associated beta-galactosidase1

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