Clonal hematopoiesis of indeterminate potential
Biomarker2 papers1 finding
- Humans2
Associations
1Frailty
upin humans1
1 study
Frailty
upin humans1
Clonal hematopoiesis of indeterminate potential is associated with frailty in humans.
Humansbloodn = 730,088
Somatic blood mutations associate with accelerated frailty and functional decline in humans · medRxiv · 1 Oct 2026 · Preprint
Latest
4Somatic blood mutations associate with accelerated frailty and functional decline in humans
In a preprint analyzing over 730,000 adults, researchers linked clonal hematopoiesis to faster physical decline mediated by T-cell changes.
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment
Single-cell and spatial profiling revealed expanded fibroblasts and localized hubs of inflammation driven by tumor necrosis factor and transforming growth factor-beta signaling.
Clonal blood mutations in ASXL1 associate with higher lung cancer risk
Researchers analyzing two large human cohorts found that ASXL1-mutant clonal hematopoiesis linked to more than triple the risk of lung cancer in smokers.