KL
GeneHomo sapiens4 papers3 findingsHGNC 6344NCBI Gene 9365Taxon 9606
In a human trial involving people with type 2 diabetes mellitus, a yoga lifestyle programme increased serum KL levels. In chondrocytes, exercise-primed extracellular vesicles activate KL, which is required to restore a youthful phenotype.
- Human trial2
- Cells1
Interventions
2Exercise-primed extracellular vesicles
upin cells1
1 study
Exercise-primed extracellular vesicles
upin cells1
Exercise-primed extracellular vesicles activate KL in cells.
Cellschondrocyte
Exercise-induced extracellular vesicles enhance aged cartilage health via microRNA-29 · Nature aging · 29 Sep 2026
Yoga lifestyle programme
upin humans1+15%
1 study
Yoga lifestyle programme
upin humans1+15%
Yoga lifestyle programme increases KL in humans (+14.65%).
Human trialin type 2 diabetes mellitusasanas, pranayama, meditation, kriyas, a satvik diet, and spiritual sessionsserum15 daysn = 74
Impact of a Short-term Yoga Lifestyle Programme on Circulating Serum Klotho Levels in Patients with Type 2 Diabetes: An Exploratory Study · Indian journal of endocrinology and metabolism · 1 Jul 2026
Effects
1Youthful chondrocyte phenotype restoration
is required forin cells1
1 study
Youthful chondrocyte phenotype restoration
is required forin cells1
KL is required for youthful chondrocyte phenotype restoration in cells.
Cellsfor anabolic effects of miR-29-expressing EVschondrocyte
Exercise-induced extracellular vesicles enhance aged cartilage health via microRNA-29 · Nature aging · 29 Sep 2026
Latest
4Exercise-induced extracellular vesicles enhance aged cartilage health via microRNA-29
A three-month aerobic program in older adults generated microRNA-29-loaded vesicles that boosted Klotho expression and enhanced cartilage health in mice.