Tumor progression
Disease1 paper1 finding
Upstream
1Senescence-associated secretory phenotype (SASP)
upin reviews1
1 study
Senescence-associated secretory phenotype (SASP)
upin reviews1
Senescence-associated secretory phenotype (SASP) increases tumor progression.
Reviewin persistent senescent cells
Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications · Journal of hematology & oncology · 29 Sep 2026
Latest
6Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
Ultrasound-activated quantum biomaterial pairs with senolytic to suppress colorectal cancer
Combining pyroptosis-inducing Pd3Sn nanostructures with the senolytic piperlongumine targets treatment-induced senescent cells and reduces metastatic tumor burden in animal models.
Blind mole-rat mesenchymal stem cells resist carcinogen-induced damage through preserved p53 signaling
Unlike human and mouse cells, blind mole-rat stem cells maintained viability and differentiation after carcinogen exposure by preserving protective gene pathways.