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Cellular senescenceSenescent cells, the SASP, and the drugs that clear or quiet them.
Aging clocksEpigenetic, blood-based and other measures of biological age.
mTOR & rapamycinNutrient sensing through mTOR, and the rapalogs that dial it down.
Partial reprogrammingYamanaka factors, epigenetic reprogramming and cellular rejuvenation.
NAD+ & sirtuinsNAD+ precursors, sirtuins and the metabolism of aging cells.
MitochondriaMitochondrial function, mitophagy and energy decline with age.
Dietary restrictionCaloric restriction, fasting and time-restricted eating.
GLP-1 drugsSemaglutide, tirzepatide and what incretin drugs do to aging.
InflammagingChronic low-grade inflammation and the aging immune system.
Brain agingCognitive aging, neurodegeneration and the aging brain.

Hyperglycemia

Disease1 paper

Animals1

Latest

2

CCN1 upregulation in diabetic wounds suppresses PINK1/Parkin-mediated mitophagy in dermal fibroblasts by regulating HIF-1α protein stability under decompensated hypoxic conditions

CellsCellular Signalling

·28 Sep

Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features

AnimalsBiomedicines

·26 Sep

Related

Arntl1
Cdkn1a1
Cdkn2a1
Cellular senescence1
Circadian clock1
Clock1
Mitochondrial dysfunction1
Mki671
Per21
Tp531
Constant light exposure1
Hepatic steatosis1
Melatonin1
p16INK4a–RB pathway1
p53–p21 pathway1
Structural entropy1

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