Constant light exposure

1. Constant light exposure increases cellular senescence in rats.

   “Constant light exposure induces hepatic alterations that share multiple features with aging-associated phenotypes, including steatosis, cellular senescence, mitochondrial dysfunction, and circadian disruption.”

   Animals24 h/dayliver24 h/day3 monthsmalesn = 120

   Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features · Biomedicines · 31 Aug 2026

Cellular senescence →

1. Constant light exposure increases structural entropy in rats (21.4%).

   “Entropy increased by 21.4% and showed strong correlations with steatosis score (r = 0.93)”

   Animals24 h/dayliver24 h/day3 monthsmalesn = 120

   Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features · Biomedicines · 31 Aug 2026

Structural entropy →

1. Constant light exposure increases Cdkn2a in rats (23.8-fold).

   “marked increases in p16 (23.8-fold), p21 (6.7-fold), p53 (+80.9%), steatosis, hyperglycemia, and mitochondrial dysfunction”

   Animals24 h/dayliver24 h/day3 monthsmalesn = 120

   Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features · Biomedicines · 31 Aug 2026

Cdkn2a →

1. Constant light exposure decreases melatonin in rats (>2-fold decrease).

   “Constant light exposure caused a >2-fold decrease in serum melatonin”

   Animals24 h/dayserum24 h/day3 monthsmalesn = 120

   Structural Entropy of Liver Histological Sections as an Integrative Index of Tissue Disorganization in Constant-Light-Induced Hepatic Remodeling with Aging-Associated Features · Biomedicines · 31 Aug 2026

Melatonin →