NfL
Biomarker2 papers1 finding
- Human trial1
- Humans1
Interventions
1Fenofibrate
downin humans1
1 study
Fenofibrate
downin humans1
Fenofibrate decreases NfL in humans.
Human trialin chronic traumatic brain injuryplasman = 40
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate · Science translational medicine · 30 Sep 2026
Latest
2Human trialInflammaging
Cranial bone marrow monocytes drive brain injury inflammation and respond to fenofibrate
Targeting PPARα deficiency in cranial bone marrow monocytes improved cognitive function and reduced neurodegeneration markers in older patients with chronic brain injury.
HumansBrain aging
Peripheral immune cell profiles predict cognitive decline in older adults
An immune risk score tracking immunosenescence correlated with markers of neural injury and neuroinflammation rather than classical amyloid or tau pathology.