Mitochondrial Quality Control Imbalance in the Heterogeneity of Parkinson's Disease: From Selective Vulnerability to Stratified Transformation
Abstract · CC BY
Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder in which variable symptom profiles, progression rates, and treatment responses likely reflect distinct but partially convergent pathogenic mechanisms.
- Disabled macroautophagy
- Loss of proteostasis
- Mitochondrial dysfunction
- Mitochondrial biogenesis (PGC-1α)
- Mitophagy
- Oxidative stress and ROS signalling
- Parkinson's disease
- Homo sapiens
The paper
Mitochondrial Quality Control Imbalance in the Heterogeneity of Parkinson's Disease: From Selective Vulnerability to Stratified Transformation
Chen Y, Wang C
International Journal of Molecular Sciences · 11 Sep 2026