Secukinumab
Intervention1 paper2 findings
- Animals1
Outcomes
2Temporomandibular joint osteoarthritis
downin mice1
1 study
Temporomandibular joint osteoarthritis
downin mice1
Secukinumab protects against temporomandibular joint osteoarthritis in mice.
Animalsunilateral anterior crossbite modelanti-IL-17A monoclonal antibody
Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice · Oral diseases · 30 Sep 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Secukinumab decreases cellular senescence in mice.
Animalsunilateral anterior crossbite modelanti-IL-17A monoclonal antibodycondylar cartilage
Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice · Oral diseases · 30 Sep 2026
Latest
1Interleukin-17A drives joint chondrocyte senescence through mitochondrial dysfunction in mice
Blocking the cytokine with secukinumab reduced cartilage senescence and slowed osteoarthritis progression in a mouse model.